Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. Metaiodobenzylguanidine (MIBG) is a compound that can be combined with radioactive iodine (I-131) in diagnostic imaging and therapy of neuroblastoma cancer cells. The purpose of this study is to synthesize and characterize novel benzyl guanidine (BG) derivative, which has similar active group like MIBG, and its polymer conjugated analogue (PLGA-PEG-BG) to compare their effects on neuroblastoma cancer cells with MIBG. We used click reaction method to conjugate the BG to polymer (PLGA-PEG). Dialysis method was used to purify the polymer and the synthesized structures were characterized by <sup>1</sup>H-NMR spectroscopy. Furthermore, we tested the effects of the synthesized compounds on in vivo neuroblastoma cell growing in nude mice. We found that the new compounds significantly decreased tumor growing compared to control group and also, they showed more effective growth inhibition than that of MIBG.

Therapeutic effects of novel benzylguanidine derivative on neuroblastoma tumor cells

254th National Meeting (2017)

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