The predominant source of vitamin D in humans is exposure to sunlight. Hence, the fact that people living in the sunny region of the world still suffer from vitamin D deficiency remains a mystery. Various vitamin supplementary products are sold dramatically. However, everyone admits that it is very difficult to maintain their vitamin intake on a daily basis. On the contrary, most people brush their teeth once a day at least. Combining the fact that most people brush their teeth at least once a day with the idea of easy vitamin D delivery deemed to be an effective method.    In this study, a vitamin D-deliverable toothpaste was formulated with an emulsion base that was formulated with distilled water, olive oil and emulsifying wax. On top of that, traditional essential ingredients of toothpaste (TSPP, Sorbitol, Xanthan Gum, Sodium Bicarbonate, Silica) were carefully mixed with Vitamin D and penetration enhancers Sodium Dodecyl Sulfate (SDS) and Polysorbate 80. After it was formulated, various properties of the formulation, such as the presence of abrasive particles, abrasiveness, spreadability, pH, foaming ability and cleaning ability were tested through recommended methods and were compared with commercial toothpastes, Colgate and Crest. Our formulations’ toxicity was tested by using Daphnia through serial dilution. Transepithelial electric resistance (TEER) Values of earthworm skin were monitored and its weight reduction capability of earthworm were evaluated.<br/>As a result, the vitamin D toothpaste that formulated in this study had more favorable properties in terms of its spreadability, pH and cleaning ability, but its abrasiveness and foaming ability were inferior to the two other commercial toothpastes. The daphnia study, TEER Values and L. terrestris weight reduction capability test demonstrated that this formulation intraorally increased the vitamin D delivery.    It was expected that the SDS and polysorbate 80 might facilitate vitamin D to deliver across the skin which was the epithelial tissue like intraoral area.  <br/>

Formulating a toothpaste that intraorally delivers vitamin D using penetration enhancers

254th National Meeting (2017)

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