Attention to high energy intermediates is growing because of their key role in both organic synthesis and biological applications. In particular, photochemical activation of thermally stable compounds have been successfully applied in different fields of medicine, including photodynamic therapy and bacteria inactivation. Herein we present an in vitro investigation of the bacteria inactivation induced by 4-acetylphenylazo mesylate or other arylazosulfones. Such colored stable derivatives of aryl diazonium salts have been demonstrated to be valuable photoprecursors of either aryl radicals and aryl cations in their triplet state (3Ar+), depending on the chosen irradiation wavelength. Preliminary experiments have been carried out in the presence of 10-3 M 4-acetylphenylazo mesylate showed UV-B (366 nm) photoinduced inactivation of planktonic E. coli with some dark toxicity. A 30% decrease in bacterial colony count was observed without irradiation, and a 70% decrease was observed when irradiated with UV-B light. Control experiments carried out by UV-B irradiation in the absence of 4-acetylphenylazo mesylate that showed no bacterial inactivation. However, with 4-acetylphenylazo mesylate at higher concentration (10-2 M), dark toxicity with no bacteria growth in dark control was observed.

Photoinduced bacterial inactivation by azosulfones

254th National Meeting (2017)

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