Polymer-drug conjugates in drug delivery area were proposed to reduce leaking of drug and improve loading by chemical conjugation between drugs and polymers. Although several drug-polymer conjugates reached clinical trials, they have shown limited delivery efficacy due to slow and uncontrollable drug release. In this research, anti-inflammatory drug conjugated dextran via H2O2 sensitive linker (Nap-Dex) was synthesized and triggered drug release was evaluated. Nap-Dex nanoparticle has shown high stability in physiological conditions, and H2O2 concentration-driven drug release. Moreover, to prove wide applicability of newly prepared polymer, Nap-Dex was blended with acid-sensitive dextran and payload release was also demonstrated. These blended dextran nanoparticles (B-Dex NPs) have shown dual sensitivity with acid and ROS. B-Dex NPs released conjugated anti-finlammatory drugs from the polymers in bone marrow derived macrophages and decreased TNF-a production up to 55 %. Meanwhile, B-Dex NPs were uptaken in to the cells and released model payloads, rose bengal, by acid sensitive particle degradation.

ROS triggered release of anti-inflammatory drug chemically conjugated on dextran by boronic ester linker

254th National Meeting (2017)

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