The stereochemical analysis of amino acids is of great interest due to their crucial biological functions. A selective, rapid and highly sensitive molecular probe for accurate and simultaneous quantification of the enantiomeric excess and concentration of cysteine has been developed. The cysteine sensing is based on double <i>ipso</i>-substitution, which results in distinct chiroptical (UV and circular dichroism) signals at high wavelengths. This approach is fast, operationally simple and compatible with aqueous solutions including simulated body fluids. The probe is highly specific for cysteine. Other amino acids and biothiols, such as homocysteine and glutathione, do not interfere with the chiroptical analysis.

Chiroptical sensing of cysteine in complex mixtures

254th National Meeting (2017)

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