Chiral aziridines and N-protected chiral aziridines were synthesized from the corresponding amino alcohols and amino acids in large scale. Aziridines with small molecule were synthesized in a toluene and the toluene solution was used for the protected aziridine reactions with phosphoryl, tosyl, nosyl, Boc group with excellent to quantitative yields. And the examples of ring opening applications will be discussed.<br/>

Synthesis of chiral aziridines from chiral amino alcohols and ring opening reactions of aziridine ring

254th National Meeting (2017)

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