Aggrecan is an ultra-high MW proteoglycan with bottlebrush architecture in articular cartilage, and accounts for the remarkable mechanical properties of cartilage. However, detailed understanding of structure-property relationships is hampered by the heterogeneity of the natural aggrecan. We synthesized a series of bottlebrush polyelectrolytes resembling the aggrecan structures with controlled, variable macromolecular parameters. These bottlebrush polymers were investigated using rheology and scattering at different salt concentrations to elucidate the structure-property relationships of such bottlebrush polyelectrolytes.<br/>

Solution behavior of bottlebrush polyelectrolytes

254th National Meeting (2017)

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