Metal organic materials (MOMs) are a class of porous materials composed of organic ligand molecules linked through metal clusters (molecular building blocks or MBBs) that have the potential to serve as platforms for a wide array of applications including novel drug delivery, gas separation and storage, catalysis, biomimetic chemistry, chemical and biological sensing and environmental remediation to name only a few. Drug delivery applications for MOMs are of increasing interest as these materials can contain a high weight percent of biologically active compounds within the large interior cavities while the relatively small pore sizes enables effective time release. Here we describe the development of a novel photodynamic therapy application of MOMs in which a Ru(II)(2,2’-bipyridine)2(BAM)2 (BAM = Bio-Active Molecule) cluster is encapsulated within the cavities of the Zn-based polyhedral MOM, USF2. Exposure of the new materials to white light results in the photoejection of the BAM and subsequent egress to the bulk solvent through the exterior pores. The target BAM for the initial photodynamic MOF development (PDT-MOF) are 4 – Amino pyridine (4APY), Methyl 4-aminobutyrate hydrochloride (GABE) Y- Aminobutyric acid (GABA) with Ru(II)(2,2’-bipyridine)2(acetonitrile)2 serving as a small molecule control. The Fe based MIL series of MOFs and various copper MOF’s were explored for Ru(II)(2,2’-bipyridine)2(BAM)2 encapsulation due to their stability in water, and optimal pore sizes. The synthesis, structural characterization and results of encapsulation of these new materials are reported.

Towards photodynamic therapy MOFS: Encapsulation of photoactive Ru(II)(2,2’-bipyridine)2(bio-active molecules)2 into metal organic frameworks

254th National Meeting (2017)

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