Ion pairing between charged groups on proteins, polypeptides, or small organic molecules with ions in salt solutions has been studied with numerous model systems. The results usually reproduce a Hofmeister series, rather than the more selective ion effects that are often found in biological system. As such, we have begun to explore preorganized systems with multiple charged moieties that more closely resemble the behavior of ion channels, protein binding pockets and other recognition sites for anions and cations. Specifically, the current study explores how polyanions influence the binding of monovalent and divalent metal cation. Thermodynamic measurements are provided along with complementary spectroscopic information from Raman Multivariant Curve Resolution (Raman-MCR), a technique that probes hydration structure of solvated organic molecules. Holistically, these results demonstrate how incorporation of supramolecular preorganization into ion-specific studies is an important step in understanding Hofmeister Chemistry and when it can be superseded by more ion specific effects.

Osmolytes to ions: Elucidating the effects of preorganization on ion-ion interactions

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.