Supramolecular structures based on peptide amphiphiles (PA) are revolutionizing  diverse areas of biomedical research including: tissue engineering and regenerative medicine, drug delivery, and targeting and imaging. However, the full potential of PA as antibacterial agents has not been widely explored yet. In this talk, we will present our efforts to develop supramolecular antibacterials based on PA. We will discuss the synthesis and purification of several new PA molecules. We will present a full characterization of the various supramolecular shapes we have made by TEM, AFM, DLS . We will also present antimicrobial data and explore the mechanism of action of these nanotherapeutics. We will present the toxicity of the nanostructures in vitro and in vivo. Finally, we will discuss the observed supramolecular structure-activity relationships (SSAR).

Development of supramolecular antibacterials: Understanding supramolecular structure-activity relationships (SSAR)

254th National Meeting (2017)

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