Water-soluble linear polymers with high-acid functionality are commonly used in oral care formulations to provide benefits including but not limited to, active complexation, delivery, and inhibition of the deposition and growth of bacteria, commonly referred to as ‘anti-attachment’. Unfortunately, structure activity relationship studies of these polymers are scarce; without theses studies the ability to design a polymer with a desired property (e.g. anti-attachment) is not feasible. Multifunctional anti-attachment amphiphilic molecules (AMs) featuring a sugar backbone, hydrophobic arms, a polyethylene glycol tail, and a chemical anchor were found to effectively deposit on soft ceramic surfaces and reduce bacterial adhesion. The chemical compositions of the AMs were fine-tuned to provide AMs that coordinate with ceramic surfaces to form self-assembled monolayers with controlled release.  A graft-to approach was used to investigate the effect of the chemical anchor on the AM deposition and retention. The chemical composition, absorption/desorption, and wettability properties of the bioactives and bioactive coated surfaces were investigated using nuclear magnetic resonance, X-ray photon spectroscopy, quartz crystal microbalance, and contact angle. In addition, ability of the AMs to provide anti-bacterial attachment on a ceramic surface was evaluated in vitro using bacterial repulsion assays. The correlation between surface retention and anti-attachment properties of the AMs demonstrates the feasibility and tunability of using these polymers as bioactive agents that provide anti-attachment benefits on ceramic surfaces.<br/>

Reduction of bacterial attachment on ceramic surfaces: Using amphiphilic molecules to enhance surface retention and prevent attachment

254th National Meeting (2017)

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