Hypertension affects about 1 in 3 Americans over the age of twenty years old. The disease is referred to as the “silent killer”, as it can remain asymptomatic for many years, manifesting later in life as a myriad of other diseases. Cardiovascular diseases, diabetes, peripheral artery disease (PAD), cerebrovascular diseases and kidney failure are some of the illnesses associated with hypertension. The recent reports of the antispasmodic activity of 7-epiclusianone has renewed our interest in the bioactivity of these clusiaceae bicyclononanes. In our continuing study of the Louisiana species of <i>Hypericum hypericoides,</i> we re-isolated 7-epiclusianone and its epimer clusianone along with several unknown metabolites which contain a basic bicyclononane core. We herein describe the antihypertensive activity of 7-epiclusianone and several other the related bicyclononanes.

Antihypertensive activity of 7-epiclusianone and other bicyclononanes from <i>Hypericum hypericoides</i>

254th National Meeting (2017)

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Antihypertensive activity of 7-epiclusianone and other bicyclononanes from Hypericum hypericoides