The Comprehensive Environmental Response, Compensation, and Liability Act, as amended, (CERCLA; also known as Superfund), authorizes the President to respond to chemical releases or threatened releases of chemicals into the environment. A significant challenge facing the Superfund program is proactively identifying novel substances of concern, understanding their health effects, and providing robust, consistent evaluations of potential chemical properties and toxicity. To address this problem, EPA’s Superfund Program has partnered with the Office of Research and Development’s National Center for Computational Toxicology to develop a program specific dashboard to aggregate data on over 740,000 chemicals. These data include experimental and predicted physicochemical property data, bioassay screening data associated with the ToxCast and Tox21 efforts, product and functional use information, predictive toxicity models, analytical methods and a myriad of related data of value to environmental scientists. Specific to the Superfund program, this dashboard incorporates “screening levels” for chemicals using standard Superfund approaches. These screening levels are risk-based concentrations derived from standardized equations incorporating physiochemical properties, toxicity, and assumptions about human exposure to calculate medium specific concentrations which are considered by the agency to be protective for humans over a lifetime of exposure. This dashboard enables users to quickly access information on novel compounds and provides estimates of human health risks, along with SLs, to facilitate site specific risk assessment. The data in the dashboard are intended to assist risk assessors, project managers, and the public to identify emerging contaminants and facilitating access to available <i>in vitro, in vivo</i>, and <i>in silico</i> data.

Applications of the web-based CompTox Chemistry Dashboard to support emerging contaminants in the Superfund Program

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.