Assembled vesicles were the one of the most intriguing platform for drug delivery systems. With the help of such vesicles, enhanced permeability and retention effect and reducing side effect of drugs can be achieved due to its unique conformation. Over the past few decades, a variety of efforts have been made to push forward applications of vesicles, e.g. vesicles are introduced with stimuli-responsiveness unit, which could change its conformation by specific stimuli, to achieve controlled release; the surface of vesicles are engineered such as PEGlation or crosslinking to elongate circulation time and increase the stability; targeting molecules are used and modified on vesicles<sup> </sup>to accumulate vesicles to specific site and induce accurate delivery, size and shape of nanoparticles are synthesized to study and modulate cell uptake process etc. Recently, people found that multidrug delivery showed synergy effect in cancer therapy, the observed efficiency is greater than the sum of the efficiencies of the individual drugs, which<sub> </sub>may further expand opportunities of drug delivery applications. Among them, several types of drugs are studied and show success, however, further studies are hindered due to the specific carrier or method. Thus, a general platform is still desirable which can achieve a variety of functions modularly while co-load hydrophilic/hydrophobic small molecules, oligonucleotides and peptides in a sequential and controllable manner. In 2014, the ‘frame guided assembly’ (FGA) strategy had been reported that may fulfill requirement mentioned above through assembly process and DNA nanotechnology. Herein, based on the principle of FGA, we report a vesicle which can sequentially load multiple cargos and also achieve specific functions through modular design. We demonstrate this vesicle would be an outstanding platform for drug delivery in the future.

Modularly designable vesicle for sequentially multiple loading

254th National Meeting (2017)

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