The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been used for many decades around the world. Many scientific studies on its concentration in food, air, soil and water have been published, but concentration data in these media alone are not informative with regards to human health and risk assessment. Ideally, human exposure estimates in a common metric are required, permitting a comparison of doses across exposure datasets. In addition, numerous biomonitoring studies of 2,4-D exist, primarily in the form of measured levels in urine, but are not directly comparable to measurements in environmental media or calculated exposures.<br/>Building off the examination of quality and representativeness of environmental- and biomonitoring-based 2,4-D data, the next step is to develop a means to compare the data.  The environmental data were input into several existing exposure models in order to convert them to a common exposure metric of mg/kg-day. The converted data were subsequently inputted into two Biomonitoring Equivalents (BEs) methods in order to estimate the related urinary concentrations, enabling comparison with published biomonitoring data. The BE method was chosen as it provides a deterministic estimate of the urinary concentrations that are easy to interpret and to compare with other data. Using this approach, the relative importance and magnitude of different media can be estimated, as well as their significance when compared with biomonitoring data.<br/>

2,4-D Human exposure data: Harmonisation of published data

254th National Meeting (2017)

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