Hospital-acquired infections (HAI) are becoming important causes of mortality and morbidity in hospitals. Although frequent cleaning with disinfectants can effectively prevent the contact transmission of microorganisms, surface corrosion, microbial tolerance and potential harmful residues resulting from ordinary chemical disinfectants are main concern. Blue lights are recently reported with obvious bactericidal activity. This study works on the bactericidal activities and mechanism of two types of blue light-470nm and 405nm. Results shows that 470nm and 405nm blue light effectively reduce the gram positive and negative bacteria, and also have excellent performance on MDROs . By measuring the sub-lethal rate, and phosphate, DNA, and Protein leakage from the bacteria, it reveals that 405nm light can deconstruction of the bacteria membrane. UMU test explain the bactericidal mechanism of 470nm light which is destroy the structure of bacterial DNA.

Bactericidal activity and mechanism of high intensity narrow wavelength blue light LED

254th National Meeting (2017)

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