The alternating copolymerizations of epoxides and CO2 or anhydride are used to prepare di-hydroxyl end-capped polycarbonates or polyesters. The hydroxyl end groups are used to form block copolymers by initiating ROP of lactones or cyclic phosphoesters. The block copolymers also feature alkene groups in each repeat unit which are either terminal (vinyl) or internal alkene substituents. The alkene groups are reacted to form functionalized polymers targeted for biomedical applications – For the first example, the reaction with thiol-amines and subsequent quaternization allows the formation of antimicrobial surfaces. Alternatively, the alkenes are differentially reacted to produce alternating sequences of (ABAB)n repeats, where A features a hydroxyl substitute and B includes groups such as amine or acid. Finally, the scope to apply brush copolymers in bone tissue engineering will be highlighted.

Semi-renewable CO2-derived polycarbonates and block copolymers for biomedical applications

254th National Meeting (2017)

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