METIs are known to show insecticidal and miticidal activities. Tolfenpyrad is one example of a commercialized product with this MOA. Despite the broad range of activity often observed for these compounds in greenhouse screens, the use is often limited by unfavorable regulatory properties. Starting from a fungicide lead structure we identified pyridylmethyl sulfonamides as a new METI subtype with interesting fungicidal and insecticidal activity. However, the mammalian toxicity observed for this class was still not in the desirable range. The introduction of a quinoline moiety significantly reduced the regulatory concerns. The quinoline sulfonamides lost the fungicidal properties, but still showed good insecticidal activity. Further exploration of the compound class will be described.

Synthesis of quinoline sulfonamides as insecticidal METI inhibitors with low mammalian toxicity

254th National Meeting (2017)

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