The use of surrogate exposure monitoring data, i.e., data developed with one pesticide and applied generically to another, has a long history for agricultural pesticides for both pesticide handlers (e.g., mixer/loader/applicators) and post application exposure in agriculture.  This surrogation has been extended to residential exposure assessment as presented in the EPA OPP’s Residential Exposure Assessment Standard Operating Procedures.  Biomonitoring, although recognized as the “gold standard” of exposure monitoring, has frequently been relegated to the role of validation of passive dosimetry, and is not often used as a surrogate or generalizable data source.   <br/> <br/>This presentation provides a case study regarding the evaluation of estimates of adult applicator and post-application (adults and children) exposure (and absorbed dose) following the use of residential pet spot-on products containing pyrethroids (e.g., cyphenothrin biomonitoring data surrogated to etofenprox).  This case study presents a discussion of the important factors in identifying appropriate surrogate biomonitoring data for applied exposure analyses of pyrethroids including: 1) use pattern, e.g., where product application is made, and associated exposure pathways/routes; 2) amounts of formulation that are used; 3) formulation type and physical form; 4) physicochemical properties; 5) chemical class / mode of action; 6) relative rates (or percentages) of dermal absorption; 7) metabolic pathway and biomarker characterization; 8) application device technology; 9) re-application interval; 10) treated pet species; 11) target pests; and 12) product label instructions.

Surrogating biomonitoring data: Case study of pyrethroids in pet spot-on products

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.