Dietary supplements of ionic silver, colloidal silver, and silver hydrosols are widely commercially available. Intended for oral ingestion, the transformations of these nanostructured silver materials is measured using a simulated gastrointestinal fluid system. Using physiologically relevant sample volumes, concentrations, temperatures, and mixing times, a sample is added to a simulated saliva; this mixture is added to a simulated gastric fluid; and finally the new mixture is added to a simulated intestinal fluid. Comparison of commercially available dietary supplements is made to well defined samples, including silver nitrate and citrate-capped silver nanoparticles, enabling hypothesis testing and evaluation of "real world" results about the transformations these product may undergo after ingestion.  A range of commercially feasible characterization techniques will be presented, including transmission electron microscopy (TEM), atomic absorption spectroscopy (AAS), pH, and dynamic light scattering (DLS).  An analysis of the impact of the transformations under relevant conditions will be presented, with a focus on the change in availability of bioactive silver ions.

Measurements of transformations of silver dietary supplements in simulated gastrointestinal fluids

254th National Meeting (2017)

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