<br/>The registration process for a pesticide is lengthy and expensive. However, the impact of expense and time can be reduced by the delivery of an analytical method that is rugged, robust, and well-documented. Frequently, analytical procedures are inherited from the metabolism development work. These procedures are further validated and become the analytical method that is used for residue analysis. A more enlightened approach to the production of an analytical method is to consider it as being designed, rather than developed. After the development of the metabolism procedure, the procedural steps can be further designed for use as a residue analytical method. Specific issues that should be evaluated during the design process include (but are not limited to): ease of use/through-put, scaling (solvent/waste), cross-talk, documentation of critical details, pH, and matrix variety. Changing the thought paradigm around the creation of the analytical method (i.e., design instead of development) allows for the manipulation of key parameters. When a method is designed, focus can be made on ensuring that the procedures cater well to the reduction of cost and time associated when employing the method. By reviewing a number of issues found during development, in view of necessary performance criteria for validation and transfer, these design items can be determined, discussed, and improved upon.

Proof of concept: Cost savings start with method design not development

254th National Meeting (2017)

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