In the scientific review of pesticides to insure the safe use, an important component of a human health and safety assessment is an estimation of dietary exposures.  Direct and indirect drinking water intake constitute a key exposure pathway of aggregate exposure.  The National Health and Nutrition Examination Survey/“What We Eat in America” (NHANES/WWEIA) survey collected two-day food and drinking water intake information from over twenty four thousand respondents for the years of 2005-2010.  The U.S. Environmental Protection Agency (EPA) developed the Food Commodity Intake Database (FCID) to utilize the survey information in human safety assessments.  The Dietary Exposure Evaluation Model (DEEM-FCID) and CALENDEX software have been developed to estimate dietary exposures arising from the use pesticides.  The Cumulative and Aggregate Risk Evaluation System - Next Generation (CARES-NG) software is under development and offers an alternative approach to calculate dietary exposures.  Both software rely on two-day food consumption data.  Therefore, the method in which short-term data is used to estimate long-term dietary exposure is crucial to the accuracy of aggregate exposure.  The CARES-NG software incorporates refinements in modelling long-term dietary exposures by i) identifying a set of individuals with similar diet patterns to fill a single 365-day longitudinal consumption profile ii) using body-weight growth models to take into account the changes in the body-weight of children, adolescents and pregnant women during the 365-day profile.  The objective of this case study is to compare the dietary exposure estimate from drinking water using the two assessment tools, DEEM/CALENDEX and CARES-NG.  The concepts and frameworks that support the simulation methodologies as well as comparison of analyses will be presented for single point, distributional and time-series drinking water assessment scenarios.  While there are some differences expected at the estimation of upper tail of exposures, the results from this example generally support the notion that drinking water exposures generated from the two software are comparable.

Comparison of CARES-NG and DEEM/CALENDEX acute and long-term drinking water exposures

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.