This presentation will highlight recent developments in Analytical Chemistry technology that have opened new opportunities to impact Medicinal Chemistry projects. One example will describe how high throughput synthetic screening efficiency and data analysis quality can be exponentially improved through the use of customized software solutions. In addition, highlights of the utilization of SFC/MS technology combined with unique stationary phases to fully resolve, identify and quantitate reaction mixtures which were otherwise intractable using RP-HPLC/ESI-MS (the “gold standard”) will be presented. Finally, we will demonstrate several unique characteristics of SFC chromatography, which enable the development of a methodology for measuring intra-molecular hydrogen bonding differences between matched pairs of compounds.

Leveraging analytical technologies to impact medicinal chemistry projects

254th National Meeting (2017)

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