Topical delivery is the best route for administrating active ingredient to skin treating various skin diseases. Many types of formulation including ointment, cream, lotion and gel are available in the market have one or more disadvantages, such as uncomfortable oily texture, low stability, and inability to encapsulate hydrophobic drugs. To solve these problems, emulsion gel which possesses the property of both emulsions and gel had be developed. According to the previous studies, the smaller particle sizes in emulsions will allow higher skin permeation rate of active compound into the epidermal layer.. Thus, in this work, a new topical formulation is developed as nanoemulsion based gel system aiming to enhance the skin permeability while overcoming the disadvantages of other topical formulation. To find the optimum formulation composed of adlay oil, a potent whitening agent, samples composed of various ratio of Tween 80, DI water, and Pluronic® F127 were produce and summarized into pseudo-ternary phase diagrams. To identified the optimum emulsion gel formulation, dynamic laser scattering, accelerated stability test, and rheometer measuring rheology were used to study the physical properties of emulsion gel formulation. According to the results, emulsion containing 60% water and 7:3 ratio of adlay oil to Tween 80 (20% w/w) has the smallest particle size (70 nm) after being homogenized by high pressure homogenization for 2 cycles at 1000 bar pressure. Next, the gelled-emulsion system formed by using Pluronic® F127 and nanoemulsion with particle size smaller than 100 nm remained stable when subject to five of temperature cycling testing. Using in vitro guinea pig skins permeation experiments, nanoemulsion gel was found to significantly enhance the skin penetration rate of active components compared to emulsion, emulsion gel and nanoemulsion. The results from this study indicated that nanoemulsion gel system, could enhance skin permeability of active compound due to its smaller particle size, thixotropic property, and mucoadhesive property, which could strengthen the healing efficacy such as skin whitening and many more skin related illness.

Preparation of adlay oil based nanoemulsion gel as novel delivery system for topical application

254th National Meeting (2017)

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