Our research group continues to explore the chemical modification of natural products to identify new bioactive agents that could be useful in the development of new chemotherapeutic drugs for the treatment of castration resistant prostate cancer. In our attempt to study some newly designed 1,4-benzodioxane derivatives in castration-resistant prostate cancer, we found the antioxidant natural product, gallic acid, an attractive scaffold for chemical transformation to unique 1,4-benzodioxane-6-carboxylic acid derivatives. In this study, a new library of 6,8-disubstituted 1,4-benzodioxanes, including 1,4-benzodioxane-emetine hybrids, were synthesized for studies in our prostate cancer drug development program. <br/>

Design and synthesis of 1,4-benzodioxane-6-carboxylic acid derivatives for studies in prostate cancer drug development

254th National Meeting (2017)

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