The estrogen-related receptors (ERRs) were the first orphan nuclear receptors to be identified and as their name suggests are similar to the estrogen receptors (ERα and ERβ) but do not bind endogenous ER ligands. However, the synthetic ER ligand 4-hydroxytamoxifen has been shown to bind to ERRγ as an inverse agonist. Additionally, a non-selective ERRβ/γ agonist GSK4716 has also been reported. With crystal structures of both ligands in ERRγ available, we have taken a structure-based drug design approach to develop new chemical templates that act as selective modulators of ERRγ. This poster will describe the synthesis and basic structure-activity relationships of these novel thiophene and pyrazole based templates.

Efforts towards the development of new ERRg modulators via structure-based drug design

254th National Meeting (2017)

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