Integration of cross-coupling into the olefin dicarbofunctionalization manifold has the potential to create a methodology of unparalleled synthetic power to construct complex molecules in one step. However, the development of this important method has met with only limited success due primarily to complications by beta-hydride elimination from organotransition metal intermediates. In this talk, we will present our different strategies that enable Cu, Ni and Pd-catalysts to difunctionalize olefins with aryl halides and organometallic reagents in a wide variety of molecular backbones. Mechanistic pathways pertaining to these new reactions will also be discussed.

Dicarbofunctionalization of olefins by cross-coupling

254th National Meeting (2017)

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