While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses have opened new vistas in drug discovery, the industry is facing a serious innovation deficit. Critics suggest that “we have become high throughput in technology, yet have remained low throughput in thinking”. Post marketing failures of blockbuster drugs have become major concerns of industries, leading to a significant shift in paradigms and integration of discovery and process research. Process Chemistry / Route Selection are pivotal activities in the path of a drug from concept to commercialization. Medicinal chemistry synthesis routes are low yielding and fraught with capricious reactions, tedious chromatography and scale-up problems. Research by the authors and their collaborators / teams led to development of novel, cost efficacious, scalable processes for chiral molecules natural and synthetic. Processes were efficient: development of new methodologies resulted in over 100 fold reduction in costs and dramatic increases in reaction efficiencies and yield. These concepts for “Process Chemistry Driven Drug Discovery” have been back-integrated into drug discovery methodologies and have led to the discovery of new chemical entities for clinical development. A unique combination of creativity with sophisticated technology, strategic collaboration, global commerce and refined logistics led to discovery of new drugs. The essential complement of expertise in chemistry and infrastructure facilities allied with strong institutional linkages built up with various universities and pharmaceutical industry ensured successful up scaling, seamless technology transfer and implementation of new technologies. The authors have implemented newer strategies such as “Reverse Pharmacology” and “Hybrid Molecule Synthesis” to generate bioactive molecules for Drug Discovery and Development

Building international businesses based on integration of basic and applied research: Value creation by collaboration

254th National Meeting (2017)

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