The DuoBody® platform represents a versatile, elegant and robust technology for the generation of bispecific antibodies. This platform is based on the convenient post-production method of controlled Fab-arm exchange which yields bispecific antibodies that retain the molecular structure and quality attributes of therapeutic IgGs. The process is proven to be highly robust with linear scalability from bench to manufacturing scale. This presentation will highlight recent insights in the manufacturability and analytical characterization of, as well as control strategies applicable to DuoBody products.

DuoBody technology: A versatile platform for bispecific antibody discovery and development

254th National Meeting (2017)

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