It is demonstrated that carboxylic acid-functionalized titanium dioxide (TiO2) NPs produce significantly higher levels of reactive oxygen species (ROS) after visible light irradiation (400 nm to 800 nm, 1600 mW/cm2) in comparison to nonfunctionalized TiO2 NPs. The level of ROS produced under these irradiation conditions was not capable of generating oxidatively induced DNA damage in a cell-free system for TiO2 concentrations of 0.5 mg/L or 5 mg/L. In addition, specific incorporation of the acrylic acid-functionalized TiO2 NPs into dental composites allowed us to utilize the generated ROS to enhance photopolymerization (curing and degree of vinyl conversion of resin adhesives and create mechanically superior and biocompatible materials for dental applications. The modified TiO2 materials and dental composite materials were extensively characterized using TGA, electron microscopy, FTIR spectroscopy, and EPR. Our findings suggest that NP-induced ROS may be useful to produce enhanced nanocomposite materials for selected applications in the medical device field.

Biophysical characterization of functionalized titania nanoparticles and their application in dental adhesives

254th National Meeting (2017)

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