Lipid peroxidation gives rise to carbonyl species. Some of these carbonyl compounds are reactive carbonyl species that play a role in the pathogenesis of numerous human diseases. Oils are ubiquitous sources that can be easily oxidized to generate these compounds highly toxic reactive carbonyl species such as acrolein, crotonaldehyde, trans-4-hydroxy-2-hexenal, trans-4-hydroxy-2-nonenal, trans-4-oxo-2-nonenal, glyoxal and methylglyoxal under oxidative stress. Using LC/MS-MS uniquely different patterns of carbonyl compound generation between omega-3 and -6 fatty acids can be observed. We also found that green and black tea extracts can prevent the oxidative formation of acrolein in seal blubber oil. With the addition of green/black tea extract, the content of acrolein was reduced, thus demonstrating the antioxidative effect of tea polyphenols. Further LC-MS analysis revealed the formation of new adducts of equal molars of acrolein and EGCG. Thus, EGCG’s direct trapping of acrolein may contribute to the inhibition of acrolein formation in the peroxidation of seal blubber oil.

Reactive carbonlyl species from the oxidation of omega-3 and omega-6 fatty acids and method for their intervention

254th National Meeting (2017)

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