Ultrasensitive real-time imaging of cancer cells based on biosynthesized nanoscale probes Xuemei Wang State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096, China Cancer is still one of the leading causes of death all around the world. Effective detection of cancer before the metastasis to vital organs increases the survival rate of the cancer patients. So early cancer diagnosis remains a critical strategy for reducing cancer mortality and improvement of the cure rate. Diagnosis and therapy in combination with nano-biosynthesized probes may offer an alternative promising and overcome the difficulty. And the early diagnosis based on some biosynthesized smart nanoscale probes could be a convenient and valuable way for a successful theranostics of cancers. Thus, we have recently established the new in vivo target bioimaging and highly sensitive real-time analysis method based on bio-synthesized fluorescent nanoclusters from live cells as labeled probes, which demonstrate the striking characteristics of the excellent biocompatible, highly sensitive, rapid and low cost to accurately identify earliest possible trace amounts of neoplastic cells. Meanwhile, we have further explored new theranostics strategies for targeting disease like cancers through the combination of the multi-mode imaging techniques with the in-situ biosynthesized multifunctional nanoclusters (i.e., biosynthesized clusters with fluorescent and magnetic properties, etc.). Moreover, we have constructed the ultra-sensitive bioanalysis system based on the transparent microelectrode array and biosynthesized probes to detect the target diseased cells and other related bioactive molecules.

Ultrasensitive real-time imaging of cancer cells based on biosynthesized nanoscale probes

254th National Meeting (2017)

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