Knowledge in glycomics research has provided numerous benefits in diagnosis diseases and medical treatment. However, the complexity of carbohydrates makes accessing homogeneous samples difficult. The development of new glycoconjugation reactions will serve as tools to facilitate glycomics investigations. Herein, a novel multifunctional neoglycoside linker has been synthesized and efficiently incorporated into unprotected carbohydrates. This auxiliary-linker displayed broad advantages in isolation and purification of complex carbohydrate mixtures, stability during extension by glycosyltransferases, and enables direct conjugation to biomolecules or chemical probes.

Development of a multifunctional neoglycoside linker for applications in glycomic research

254th National Meeting (2017)

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