The use of electronic cigarettes as an alternative to tobacco cigarettes has become increasingly popular over the past few years. The liquids used for the electronic cigarettes have have only been regulated since August 2016. In the present work, evolved-gas analysis gas chromatography (EGA-GC) has been employed to determine nicotine levels in the liquids and most of the nicotine levels have been found to be below the labeled amounts. A hypothesisis for the low levels of nicotine is that the nicotine is being oxidized to the nicotine N-oxide in the e-cigarette solution. A thermally assisted rearrangement of the nicotine N-oxide was employed to allow for both qualitative and quantitative analysis by HPLC, EGA-GC, and HNMR. The results of this work will be presented.<br/>

Determination of nicotine and nicotine N-oxide in e-cigarette liquids

254th National Meeting (2017)

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