Recent progress in the development of innovative new strategies and methods for the efficient synthesis of topologically complex bioactive natural products will be discussed. These methods are intended to be simple and reliable, facilitating ready adoption by researchers in related fields and use in contexts beyond the initial target. We are motivated by targets with long-standing synthetic challenges and promising bioactivity, such as polycyclic alkaloids bearing a tertiary aliphatic amine and disulfide- and thioether-linked and macrocyclic polypeptide natural products. These complimentary structural classes have great potential as lead targets and as biological tools. Chemical synthesis offers unparalleled flexibility in accessing analogs to tune the structure and improve selectivity for the target of interest, and new strategies and reaction methods expedite this process.

Strategies and methods for the synthesis of topologically complex natural products

254th National Meeting (2017)

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