Our research is focused on harnessing the untapped reactivity of cheap and abundant chemical feedstocks in organic synthesis to enable the late-stage functionalization of complex natural products and other medicinally-relevant molecules. We have recently developed an approach for the selective β C-H functionalization of alcohols, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. This new radical chaperone strategy enables one to selective target and manipulate remote C-H bonds and promote a variety of unprecedented C-H functionalizations within molecules of biological and industrial interest.

β C-H functionalization via radical relay chaperones

255th National Meeting (2018)

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