Inorganic nanoparticles and surfaces can either accelerate or inhibit the fibrillation of amyloidogenic proteins and peptides, depending on the nanoparticle features (material, size, shape) and the experimental conditions of the experiment [1]. A few general mechanisms leading to acceleration and inhibition have been proposed; much less is understood on the role of the specific interactions between a given peptide and a given surface/nanoparticle in affecting fibrillation propensity. In this contribution, our atomistic simulation results for amyloid-beta peptides [2] and b2-microglobulin protein [3] interacting with bare and functionalized gold surfaces and nanoparticles will be presented, and the possible mechanisms leading to inhibition or enhancement of fibrillation will be discussed. Funding from EU under ERC-CoG grant no. 681285 is gratefully acknowledged.<br/>[1] Linse et al. PNAS 2007, 104, 8691<br/>[2] L. Bellucci et al. Nanoscale 2016, 8, 8737; Nanoscale 2017, 9, 2279<br/>[3] G. Brancolini et al. ACS Nano 2015, 9, 2600; C. Cantarutti et al. Nanoscale 2017, 9, 3941

Investigating the interaction of amyloidogenic proteins with gold nanoparticles by means of atomistic simulations

255th National Meeting (2018)

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