Continuous Bioprocessing continues to be at the forefront of therapeutic protein manufacturing innovation. In addition to many challenges facing this technology, appropriate scaled down models are still in development. Continuous low pH viral inactivation remains a significant bottleneck when coupling post Protein A elution to polishing steps. Continuous viral inactivation, utilizing plug flow methodology, converts what was a trivial batch unit operation with uniform static composition into a diverse dynamic system. This study aims at manipulating relevant operational parameters in an attempt to understand their fundamental influence on flow properties and fluid dynamics to enlighten scaled down methodologies.

Characterization of flow mechanics in a scaled down continuous viral inactivation reactor

255th National Meeting (2018)

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