Understanding the interactions between nucleotides and artificial receptors is important for the development of selective molecular sensors for living cells<sup>. </sup>However, direct structural evidence showing precise interactions and bonding features of a nucleotide with a synthetic receptor is limited. Herein, we present two novel crystal structures of uridine monophosphate (UMP) and thymidine monophosphate (TMP) complexes with a macrocycle-based dinuclear receptor. Furthermore, the receptor has been shown to effectively bind nucleoside monophosphates in the order of GMP &gt; AMP &gt; UMP &gt; TMP &gt; CMP in water at physiological pH, as investigated by an indicator displacement assay.

Molecular recognition and sensing of nucleotides with a dinuclear copper(II) complex in water

255th National Meeting (2018)

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