Stability and activity are important properties of proteins such as enzymes, since they are of industrial relevance in the fields of detergents and cellulose processing. The molecular basis of stability also relates closely to contemporary issues in protein science such as the protein-folding diseases. Development of new structures that could stabilize, organize, and control the activity of proteins has been intensely investigated, yet with limited success. The major challenge is that enzyme reactivity and stability after modification is not comparable to that of the free enzyme, and enzyme recovery can be difficult. We provide a method via controlled assembly of polymers and proteins into a hierarchical structure, which can preserve protein conformation and functionality. Compared to other methods, this proposed work is more straightforward and has better control of the structural features as well as the physical properties. It is important to note that the methods developed in this proposal for the guided assembly of proteins will be broadly applicable for many enzymatic systems. <br/>

Developing hierarchical hybrid polymer-enzyme structures for biomass conversions

255th National Meeting (2018)

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