Activity-based sensing (ABS) is an emerging field that utilizes dynamic chemical reactivity, rather than conventional lock-and-key binding, to probe and manipulate biological systems. We are advancing the ABS concept and applying it to discover and decipher the biology of new chemical signals, including reactive oxygen, sulfur, and carbon species and transition metals. This presentation will describe our latest results in developing synthetic ABS probes to enable studies of redox biology using imaging and proteomics approaches.

Activity-based sensing approaches to studying chemistry in living systems

255th National Meeting (2018)

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