Metals are essential for every form of life, and the traditional view of this bioinorganic chemistry is that mobile fluxes of redox-innocent metals like sodium, potassium, calcium, and zinc are widely employed as dynamic signals while redox-active transition metals like copper and iron must be buried and protected as static metabolic cofactors to protect against oxidative stress. We have identified a new paradigm of transition metal signaling, using copper and iron as primary examples to show how such elements can influence neural circuitry and regulate fundamental behaviors such as eating and sleeping. This presentation will focus on our latest efforts in activity-based sensing (ABS) approaches for imaging and proteomics of dynamic transition metal pools.<br/>

Transition metal signaling in the brain and beyond

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.