Applications for high resolution-accurate mass (HRAM) mass spectrometric analyses allow environmental screening and quantitation methods to be expanded to include suspect and nontarget workflows. Paramount to the success of these types of applications is the ability to identify residues in environmental samples, confirm such identification using multiple attributes, and to quantify an identified target. Workflows are presented which demonstrate two different approaches for using MRM<sup>HR</sup> to achieve quantitative and qualitative analyses of microcystins in drinking water. A workflow showing the parallel application of SWATH data independent acquisition is also outlined, and the advantages and challenges of these approaches are directly compared. The capacity to achieve high resolution mass spectral data for environmental screening, monitoring, and measurement of trace level organic contaminants combined with seamless data processing for multiple workflows on a single platform is presented as an advantage to the environmental analyst interested in multiple facets of sample analysis.

Workflows utilizing SWATH and MRMHR acquisitions for microcystins in drinking water

255th National Meeting (2018)

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