Synthetic protein switches controlled with user-defined inputs are powerful tools for studying and controlling dynamic cellular processes. This talk will focus on the the development and use of small molecule-regulated protein switches that rely on intramolecular autoinhibition. Efforts to engineer small molecule-regulated protein switches that can be used to control the activity of the GTPase RAS and the endonuclease Cas9 will be described. Application of these chemical genetic systems to understanding fundamental mechanism of receptor tyrosine kinase signaling and DNA repair will be discussed.<br/>

Engineered protein switches for controlling dynamic cellular processes

255th National Meeting (2018)

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