A universal lithographic methodology for creating single molecule devices based on carbon nanomaterials as point contacts has been developed. In this talk, I will detail our rational bioassay techniques by using bridge molecules with functional side groups capable of subsequent biocompatible assembly. We have tested this approach in chemical/biological systems, including DNA hybridization, aptamer-protein interaction, and host-guest interaction. Because it is constructed from a single molecule, each device can monitor individual binding events in real time. This methodology demonstrates a connection between electrical conduction and biology that offers a glimpse into the future of integrated multifunctional sensors and devices.

Ultrafast single-molecule electrical detection

255th National Meeting (2018)

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