As powerful as modern bio-chromatography is there are still constraints in resin design, column design and operating conditions which limit performance. Packing and maintaining column hardware also limit ease of use and manufacturing flexibility. Further linear scalability is not truly achievable due to diminishing wall effects and flow distribution in large diameter columns.<br/>Chromassette™, a novel lattice supported modular chromatography device which offers intrinsic bed support through the entire resin volume, significantly reduces the above constraints. Resin designs which may have desirable performance properties that cannot operate in current columns can now be integrated with the supported bed.<br/>Chromassette opens the possibility to develop advanced adsorptive materials with large pores for fast binding and small diameters for high capacity with no need to impart typically hydrophobic cross-linking chemistries.<br/>Data will be shown on several resin prototypes packed in a supported lattice chromatography device that can achieve 5-10 fold higher productivity, with no sacrifice in yield, purity, elution volume or buffer consumption.

Releasing chromatography from the past: Integrating a new lattice supported bed and resin design to achieve hyperproductive™ affinity capture

255th National Meeting (2018)

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