Most active pharmaceutical ingredients (API) have a bitter taste – from Advil®(ibuprofen) to Viagra®(sildenafil). The bitter taste is not an issue when commercialized as gelatins, capsules, and tablets. However, some 20% of primary care patients suffer from dysphasia and thus need their medications in a liquid, chewable, or orally dissolving forms to swallow. These forms expose the API to taste receptor cells in the taste buds and bitterness can be perceived. Bitterness is mediated by up to 25 bitter receptors. The numerous routes to mitigate bitterness from peripheral to central processing will be discussed.

Bitterness of active pharmaceutical Ingredients (API): From Advil® (ibuprofen) to Viagra® (sildenafil)

255th National Meeting (2018)

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