In medicinal chemistry, organic synthesis often generates basic by-products with similar chemistry to the product. Separating these impurities from the product often becomes a challenge that only prep HPLC can achieve.<br/><br/>In this poster, we discuss how using a strong cation exchange scavenger media as the dry loading sorbent increases flash chromatograph product purity by removing many impurities.

Using in-line ion-exchange impurity scavenging to improve flash purification efficiency

255th National Meeting (2018)

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