While dendrimers have been subject to many academic studies, their perfectly branched architecture and unique set of physical properties have yet to yield widespread commercial applications.  Perhaps one of the most unique properties of well-synthesized dendrimers is their true monodispersity; however, there are limited applications where the effort required to achieve such monodispersity is practically justified.  One specialized use where monodispersity is a vital benefit is that of a mass standards for mass spectrometry calibration.  The synthetic versatility of bis-MPA polyester dendrimers enables the synthesis of a library of mass standards that exhibit a series of discrete molecular weights across a broad mass range.  Furthermore, careful selection of core functionalities can enable the masses to be tailored for specific applications, such as the analysis of protein digests.<br/>

What good is monodispersity?  Some applications of dendrimers towards mass spectrometry

255th National Meeting (2018)

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