The emergence of drug <i>resistance</i> superbugs remains a major burden to society. Since the mortality rate caused by sepsis due to superbugs is more than 40%, accurate identification of blood infections during the early stage will have huge significant in the clinical setting. Here we report the synthesis  of red/blue fluorescent carbon dots (CDs) attached magnetic nanoparticles based multicolor multifunctional CDs based nanosystems, which can be used for selective separation and identification of superbugs from infected blood samples. The reported data show that multifunctional fluorescent magneto-carbon dots nanoparticles are capable of isolating MRSA and <i>Salmonella </i>DT104 superbug from whole blood samples, followed by accurate identification via multicolor fluorescence imaging. Since multiple drug resistance superbugs are resistant to antibiotics available in the market, this article also reports the design of  antimicrobial peptide conjugated multicolor fluorescent magneto-carbon dots for  effective separation, accurate identification and complete disinfection of MDR superbugs from infected blood. The reported data demonstrates that by combining pardaxin antimicrobial peptides, magnetic nanoparticle and multicolor fluorescent carbon dots into a single system, multifunctional carbon dots represent a novel material for efficient separation, differentiation, and eradication of superbugs. This material shows great promise for use in clinical settings.

Multifunctional carbon dots for tracking and eradication of drug resistant superbugs

255th National Meeting (2018)

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